|
KMID : 1040620200260040705
|
|
Clinical and Molecular Hepatology
2020 Volume.26 No. 4 p.705 ~ p.714
|
|
|
Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease
|
|
Han Sen
Zhang Ting
Kusumanchi Praveen
Huda Nazmul
Jiang Yanchao
Yang Zhihong
Liangpunsakul Suthat
|
|
|
Abstract
|
|
|
|
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
|
|
|
KEYWORD
|
|
|
RNA, Long noncoding, Liver diseases, Etiology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|